| 产品详情 |
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| Product Name | D 4476 |
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| Description | Purity >98%. D 4476 is a cell-permeant inhibitor of casein kinase 1 (CK1; IC50 = 200 nM from S. pombe, 300 nM for CK1Delta2 ). It is a less effective inhibitor of PKD1 (IC50 = 9.1 µM) and p38Alpha MAPK (IC50 = 5.8 µM), and only weakly affects the activities of a panel of kinases tested. D 4476 blocks CK1-mediated phosphorylation of FOXO1a, RhoB, and p53. As an inhibitor of ALK5, D 4476 prevents Smad3 activation and suppresses TGF-Beta1-induced gene expression without cytotoxicity in A498 cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)1H-imidazol-2-yl]-benzamide, Casein Kinase I Inhibitor |
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| Gene, Accession, CAS # | CAS: 301836-43-1 |
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| Catalog # | LS-H7332 |
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| Order / More Info | D 4476 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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