| 产品详情 |
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| Product Name | LIM Kinase Inhibitor I, LIMKi 3 |
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| Description | Purity ~95% (HPLC). A cell-permeable pyrazolylthiazolo-isobutyramide compound that acts as a potent LIM kinase inhibitor (IC50 = 7 and 8nM against LIMK1 and LIMK2, respectively) and effectively suppresses cellular cofilin phosphorylation (IC50 ~1uM in A549 and MDA-MB-231 cultures) without affecting tubulin polymerization or inducing cytotoxicity (EC50 >10uM in A549 proliferation & colony formation assays). Shown to effectively destabilize F-actin structure in MDA-MB-231 breast cancer cells (3 to 10uM) with concomitant blockage of invasion (by 93% at 10uM). Solubility: DMSO Primary Target: LIMK1 and LIMK2 Primary Target IC50: 7 and 8nM against LIMK1 and LIMK2, respectively Secondary Target: AMPKA1, AMPKA2, DDR1, PAK3, DCAMKL2 Molar Mass: 431.3 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | LIM Kinase Inhibitor I, LIMKi 3 (N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217513 |
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| Order / More Info | LIM Kinase Inhibitor I, LIMKi 3 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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