| 产品详情 |
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| Product Name | PLX4720 |
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| Description | Purity >95%. The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer. Mutations in the kinase B-Raf are involved in a wide range of cancers. In particular, the mutation B-RafV600E occurs in melanomas and thyroid cancer but is poorly targeted by many inhibitors of wild type B-Raf. PLX4720 is an orally-available, highly selective inhibitor of B-RafV600E (IC50 = 13 nM). It is less effective against wild type B-Raf (IC50 = 160 nM) as well as several other kinases. PLX4720 induces cell cycle arrest and apoptosis in cells and xenografts expressing the mutant of B-Raf. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide, Raf Kinase Inhibitor V |
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| Gene, Accession, CAS # | CAS: 918505-84-7 |
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| Catalog # | LS-H9459 |
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| Price | |
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| Order / More Info | PLX4720 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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