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| Product Name | Recombinant Human Nephrocystin-1 |
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| Description | 1-109aa; Partial. MW: 40.3kD. Purity >90% as determined by SDS-PAGE. Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8. Does not se to be strictly required for ciliogenesis. Ses to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intrafl |
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| Size | 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.1 mg (E-Coli), 0.2 mg (E-Coli), 0.5 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Juvenile nephronophthisis 1 protein] |
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| Gene, Accession, CAS # | NPHP1, Gene ID: 4867, Accession: NP_000263.2 |
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| Catalog # | MBS1235759 |
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| Order / More Info | Recombinant Human Nephrocystin-1 from MYBIOSOURCE INC. |
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| Product Specific References | A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis.Saunier S., Calado J., Heilig R., Silbermann F., Benessy F., Morin G., Konrad M., Broyer M., Gubler M.-C., Weissenbach J., Antignac C.Hum. Mol. Genet. 6:2317-2323(1997) A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1.Hildebrandt F., Otto E., Rensing C., Nothwang H.G., Vollmer M., Adolphs J., Hanusch H., Brandis M.Nat. Genet. 17:149 |
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