| 产品详情 |
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| Product Name | Berberine Chloride (Berberine) |
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| Description | Purity ~95% (HPLC) (NMR if no UV signal). A highly potent and selective oxysterol EBI2 (GPR183) agonist (Kd) = 450pM in a saturation binding assay, and EC50 = 140 pM over EC50 = 2.1nM for its enantiomer, 7b,25-OHC, in a GTP-gamma S binding assay). Dose-dependently suppresses forskolin-induced cAMP accumulation in an EBI2-expressing SK-N-MC/CRE-b-galactosidase cell line (IC50 = 2nM), but not in control cells. Stimulates migration of LPS-activated spleen B-cells and anti-CD3/CD28-activated CD4+ T-cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor, promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells in EBI2-deficient mice. Formula: C20H18NO4+Cl- Molecular Weight: 371.8 Solubility: DMSO (10mg/ml) or H2O (1mg/ml) |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217216 |
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| Order / More Info | Berberine Chloride (Berberine) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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