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| Product Name | BRK, Active, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). BRK is another member of the non-receptor tyrosine kinases (PTKs) that contains an amino terminal SH3 and SH2 domains as well as the catalytic domain (1). Although BRK shows strongest sequence similarity to members of the Src family, there are several key structural and regulatory differences that place it on its own amongst non-receptor PTKs. The genomic structure of BRK consists of 8 exons, whose boundaries are distinct from other non-receptor PTK family members (2). Alternate splicing of the primary BRK transcript generates a distinct mRNA which encodes a truncated protein consisting of an SH3 domain and a novel C-terminal proline rich sequence. Brk transcript is expressed in the human breast tumor cell line and expression of a tumor derived Brk cDNA in mouse embryonic fibroblasts and human mammary epithelial cells supports anchorage independent growth, and in the latter potentiates the mitogenic response to epidermal growth factor. Brk expression is low or u |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | BRK, Active, Recombinant, Human (Protein-tyrosine Kinase 6, Breast Tumor Kinase, Tyrosine-protein Kinase BRK, PTK6, FLJ42088) |
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| Gene, Accession, CAS # | PTK6, Gene ID: 5753, Accession: NM_005975. |
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| Catalog # | 219501 |
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| Price | |
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| Order / More Info | BRK, Active, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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