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| Product Name | PDE2A, Active |
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| Description | Full Length. MW: ~130 kDa. Description: Recombinant full-length human PDE2A was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: PDE2A is a member of the cyclic nucleotide phosphodiesterase family. PDE2A is a cGMP-specific phosphodiesterase and hydrolyzes cGMP to 5'-GMP. TNFalpha stimulation of cells leads to an increase in PDE2A expression in a p38 mitogen-activated protein kinase (MAPK)-dependent manner (1). TNFalpha-mediated up-regulation of |
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| Size | 0.005 mg, 0.01 mg |
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| Concentration | n/a |
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| Applications | PDE Assay |
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| Other Names | [Homo sapiens phosphodiesterase 2A (PDE2A), transcript variant 1, mRNA; cGMP-dependent 3',5'-cyclic phosphodiesterase; cGMP-dependent 3',5'-cyclic phosphodiesterase; phosphodiesterase 2A; Cyclic GMP-stimulated phosphodiesterase; CGS-PDE; cGSPDE] |
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| Gene, Accession, CAS # | PDE2A, Gene ID: 5138, Accession: NM_002599.4 |
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| Catalog # | MBS515628 |
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| Order / More Info | PDE2A, Active from MYBIOSOURCE INC. |
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| Product Specific References | 1. Seybold J, et al: Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability. Blood. 2005 May 1;105 (9):3569-76. 2. Diebold I, et al: Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2. Circ Res. 2009 May 22;104 (10):1169-77. |
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