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| Product Name | PDE4A, Active |
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| Description | 332-end. MW: ~110 kDa. Description: Recombinant human PDE4A (332-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: PDE4A is a member of the phosphodiesterase family of proteins that play a critical role in regulating intracellular levels of cAMP. In vitro phosphorylation of PDE4A by the PKA-catalytic subunit increases the enzyme's sensitivity to Mg (2+), leading to a 4-fold increase in cAMP hydrolysis without affecting the Km. PDE4 is wi |
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| Size | 0.005 mg, 0.01 mg |
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| Concentration | n/a |
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| Applications | PDE Assay |
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| Other Names | [Homo sapiens phosphodiesterase 4A (PDE4A), transcript variant 1, mRNA; cAMP-specific 3',5'-cyclic phosphodiesterase 4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A; phosphodiesterase 4A; DPDE2; PDE46] |
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| Gene, Accession, CAS # | PDE4A, Gene ID: 5141, Accession: NM_001111307.1 |
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| Catalog # | MBS515634 |
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| Order / More Info | PDE4A, Active from MYBIOSOURCE INC. |
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| Product Specific References | 1. Goldhoff P, et al: Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression. Clin Cancer Res. 2008 Dec 1;14 (23):7717-25. 2. Fatemi S H, et al: Phosphodiesterase-4A expression is reduced in cerebella of patients with bipolar disorder. Psychiatr Genet. 2008 Dec;18 (6):282-8. |
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