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| Product Name | PDE10A1, Active, Recombinant, Human, GST-Tag |
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| Description | Purified (~30%). PDE10A plays a key role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. PDE10A hydrolyzes both cAMP and cGMP to nucleoside 5?-monophosphate, but exhibits higher affinity for cAMP, and it utilizes cAMP more efficiently as a substrate (Fujishige K. et al., 1999). cAMP is an critical second messenger that is required for the proper biological responses of cells to hormones and other extracellular signals. It is required for cellular communication in the hypothalamus/pituitary gland axis and for the feedback control of hormones (Alewijnse A.E. et al., 1997). cAMP is also involved in the activation of protein kinases and ion channel regulation. Source: Recombinant corresponding to aa2-789 from human PDE10A1, fused to GST-tag at N-terminal, expressed in a Baculovirus infected Sf9 cell expression system. Molecular Weight: ~116kD Applications: Suitable for use in the study of enzyme kinetics, screening inhibitors, and selectivity pro |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PDE10A1, Active, Recombinant, Human, GST-Tag (cAMP and cAMP-inhibited cGMP 3',5'-cyclic Phosphodiesterase 10A, PDE10A) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 137325 |
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| Order / More Info | PDE10A1, Active, Recombinant, Human, GST-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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