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| Product Name | CNDP1, Recombinant, Human, aa27-507, His-tag |
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| Description | Purity ~95% (SDS-PAGE). CNDP1, also known as beta-Ala-His dipeptidase, belongs to the peptidase M20A family. The shortest allelic form (CNDP1 Mannheim) was more common in the absence of nephropathy and was associated with lower serum carnosinase levels. Carnosine inhibited the increased production of fibronectin and collagen type VI in podocytes and the increased production of TGF-beta in mesangial cells. Diabetic patients with the CNDP1 Mannheim variant are less susceptible for nephropathy. Carnosine protects against the adverse effects of high glucose levels on renal cells. Source: Recombinant protein corresponding to aa27-507 from human CNDP1, fused to His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~54.9kD (489aa), 50-70kD (SDS-PAGE under reducing conditions.) Endotoxin: 3000pmol/min/ug, and as measured by the hydrolysis of carnosine/minute at pH 6.8 at 25°C. AA |
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| Size | 10ug, 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CNDP1, Recombinant, Human, aa27-507, His-Tag (Beta-Ala-His Dipeptidase, CNDP Dipeptidase 1, Carnosine Dipeptidase 1, Glutamate Carboxypeptidase-like Protein 2, CN1, CPGL2, HST2308) |
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| Gene, Accession, CAS # | Accession: NP_116038, SwissProt: Q96KN2 |
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| Catalog # | 377766 |
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| Order / More Info | CNDP1, Recombinant, Human, aa27-507, His-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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