| 产品详情 |
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| Product Name | HDAC Inhibitor XXIII, Tubastatin A |
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| Description | Purity ~95% (HPLC). A cell-permeable carbazolohydroxamate compound that acts as a highly potent, reversible and active-site zinc-binding HDAC6 inhibitor with excellent selectivity among other HDAC isozymes (IC50=0.015, 0.854, 16.4uM for HDAC6, HDAC8 and HDAC1, respectively) with no activity towards HDAC2, 3, 4, 7, 9, 10 and 11 (IC50>30uM). Shown to induce a-tubulin hyperacetylation at 2.5uM, and offer complete neuroprotection in primary cortical rat neuronal cells against homocysteic acid (HCA)-induced oxidative stress at 10uM with no noticeable neurotoxicity. Formula: C20H21N3O2 Solubility: DMSO or EtOH Molecular Weight: 371.9 |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HDAC Inhibitor XXIII, Tubastatin A (N-Hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide, HCl) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217414 |
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| Price | |
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| Order / More Info | HDAC Inhibitor XXIII, Tubastatin A from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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