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| Product Name | PARK2, Recombinant, Human, aa1-465, His-SUMO-Tag (E3 Ubiquitin-protein Ligase Parkin) |
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| Description | Purity ~90% (SDS-PAGE). Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of a 22kD O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degra |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Parkinson juvenile disease protein 2, Parkinson disease protein 2 |
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| Gene, Accession, CAS # | SwissProt: O60260 |
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| Catalog # | 374614 |
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| Order / More Info | PARK2, Recombinant, Human, aa1-465, His-SUMO-Tag (E3 Ubiquitin-protein Ligase Parkin) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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