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| Product Name | Sequestosome 1, Recombinant, Human |
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| Description | Purity ~ 90% (SDS-PAGE). Purified by using conventional chromatography techniques. SQSTM1 is an adapter protein which binds ubiquitin and regulates signaling cascades through ubiquitination. It may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 and play a role in titin/TTN downstream signaling in muscle cells. This protein also may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. Mutations in the ubiquitin-associated (UBA) domain of the sequestosome 1 protein commonly cause Paget's disease since the UBA is necessary for aggregate sequestration and cell survival. Recombinant SQSTM1 protein, fused to His-tag at C-terminus, was expressed in E. coli. Source: Recombinant corresponding to aa1-356 of human SQSTM1 6x His tagged expressed in E. coli. AA Sequence: MAMSYVKDDI FRIYIKEKKE CRRDHRPPCA QEAPRNMVHP NVICDGCNGP VVGTRYKCSV CPDYDLCSVC EGKGLHRGHT KLAFPSPFGH LSEGFSHSRW LRKVKHGHFG WPGWEMGPPG NWSPRPPRAG EA |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | Sequestosome 1, Recombinant, Human (SQSTM1, A170, EBI3-associated Protein of 60kD, EBIAP, ORCA, Oxidative Stress Induced-like, OSIL, p60, p62, p62B, Paget Disease of Bone 3, PDB3, Phosphotyrosine-independent Ligand for the Lck SH2 Domain of 62kD, Phosphotyrosine-independent Ligand for the Lck SH2 Domain p62, Ubiquitin Binding Protein p62, ZIP3) |
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| Gene, Accession, CAS # | Accession: NP_001135771 |
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| Catalog # | S0961-50H |
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| Order / More Info | Sequestosome 1, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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