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| Product Name | Artemin, Recombinant, Human (GFRalpha3-RET Ligand) |
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| Description | Purity ≤ 98% by SDS-PAGE. Endotoxin: ≤ 0.1ng/ug (1EU/ug). Artemin is a disulfide-linked homodimeric neurotrophic factor structurally related to GDNF, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. Artemin, GDNF, Persephin and Neurturin all signal through a multicomponent receptor system, composed of RET (receptor tyrosine kinase) and one of the four GFRa (a1-a4) receptors. Artemin prefers the receptor GFRa3-RET, but will use other receptors as an alternative. Artemin supports the survival of all peripheral ganglia such as sympathetic, neural crest and placodally derived sensory neurons, and dopaminergic midbrain neurons. The functional human Artemin ligand is a disulfide-linked homodimer, of two 12.0kD polypeptide monomers. Each monomer contains seven conserved cysteine residues, one of which is used for inter-chain disulfide bridging and the others are involved in intramolecular ring form |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | A3580-51 |
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| Order / More Info | Artemin, Recombinant, Human (GFRalpha3-RET Ligand) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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