| 产品详情 |
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| Product Name | Metamizole (sodium salt) |
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| Description | Purity >98%. Metamizole (sodium salt) is a nonopioid prodrug that is rapidly hydrolyzed to the metabolites 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA), which have analgesic and antipyretic effects. MAA has been shown to inhibit COX activity 8-9-fold more potently than AA (COX-1: IC50 s = 2.6 and 20.8 µM, respectively, and COX-2: IC50 s = 4.7 and 41.8 µM, respectively). These metabolites can be further acylated with arachidonic acid to form compounds that can bind to central and peripheral cannabinoid (CB1 and CB2 ) receptors and TRPV1 receptors at low micromolar concentrations. Metamizole is associated with a risk of agranulocytosis and has been banned against using in clinical and pharmacological settings in the United States since 1977. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]-methanesulfonic acid, monosodium salt, Dipirona, Metamizol |
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| Gene, Accession, CAS # | CAS: 68-89-3 |
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| Catalog # | LS-H8639 |
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| Order / More Info | Metamizole (sodium salt) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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