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| Product Name | PDE4D3 TR-FRET Assay Kit, BioAssay™ |
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| Description | Phosphodiesterases (PDEs) play an important role in dynamic regulation of cAMP and cGMP signaling. PDE4D is a regulator of airway smooth-muscle contractility, and has been identified as a potential risk predictor for ischemic stroke. Additionally, PDE4D has been associated with asthma pathophysiology and bone formation. The PDE4D gene encodes at least 9 different isoforms. Intended Use: The TR-FRET PDE4D3 Assay Kit is designed for identification of inhibitors of PDE4D3 using TR-FRET (Time Resolved Fluorescence Resonance Energy Transfer) technology. The assay is based on the binding of phosphate groups from FAM-labeled nucleotide monophosphates generated by PDE4D3 and from terbium donors to the nanoparticle binding agent. The binding will result in energy transfer from terbium to FAM and the fluorescent intensity change can be measured using fluorescence reader. Test Principle: The TR-FRET PDE4D3 Assay Kit comes in a convenient 96-well format, with purified PDE4D3 enzyme, fluorescently |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 137344 |
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| Order / More Info | PDE4D3 TR-FRET Assay Kit, BioAssay™ from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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