| 产品详情 |
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| Antigenic Specificity | GTPase Kras |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The 21 kDa guanine-nucleotide binding proteins (K-Ras, H-Ras, and N-Ras) cycle between active (GTP-bound) and inactive (GDP-bound) forms . Receptor tyrosine kinases and G protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway . GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras. However, research studies have shown that in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway . The most common oncogenic Ras mutation found in tumors is Gly12 to Asp12 (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein . Synonyms: KRAS,C-K-RAS,K-RAS2A,K-RAS2B,K-RAS4A,K-RAS4B,KI-RAS,KRAS1,KRAS2,NS3,RASK2 , |
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| Immunogen | Recombinant protein of human KRAS |
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| Other Names | Kras2|c-Ki-ras|p21|C-K-RAS|CFC2|K-RAS2A|K-RAS2B|K-RAS4A|K-RAS4B|KI-RAS|KRAS1|KRAS2|NS|NS3|RASK2|SIIR|pp21|0610011M09Rik|BC011290|P21|AI929937|K-ras|Ki-ras|Kras-2|p21B|ras|wu:fa04e08|wu:fc14b12|wu:fc23g10|wu:fj89d12|zgc:85725 |
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| Gene, Accession # | Gene ID: 3845,16653,24525 |
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| Catalog # | ABIN1683730 |
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| Price | |
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| Order / More Info | GTPase Kras Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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