| 产品详情 |
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| Antigenic Specificity | GTPase Kras |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 200 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The 21 kDa guanine-nucleotide binding proteins (K-Ras, H-Ras, and N-Ras) cycle between active (GTP-bound) and inactive (GDP-bound) forms. Receptor tyrosine kinases and G protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway. GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras. However, research studies have shown that in 30 % of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway. The most common oncogenic Ras mutation found in tumors is Gly12 to Asp12 (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein.Synonyms: KRAS, C-K-RAS, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS3, RASK2 |
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| Immunogen | Recombinant protein of human KRAS |
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| Other Names | Kras2|c-Ki-ras|p21|C-K-RAS|CFC2|K-RAS2A|K-RAS2B|K-RAS4A|K-RAS4B|KI-RAS|KRAS1|KRAS2|NS|NS3|RASK2|SIIR|pp21|0610011M09Rik|BC011290|P21|AI929937|K-ras|Ki-ras|Kras-2|p21B|ras|wu:fa04e08|wu:fc14b12|wu:fc23g10|wu:fj89d12|zgc:85725 |
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| Gene, Accession # | Gene ID: 3845,16653,24525 |
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| Catalog # | ABIN1514282 |
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| Price | |
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| Order / More Info | GTPase Kras Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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