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| Antigenic Specificity | APP / Beta Amyloid Precursor, aa44-63 |
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| Clone | polyclonal |
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| Host Species | Goat |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | serum |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA (1:1500), IHC, IHC-Fr (1:5000), IHC-P (1:100), WB (1:1000) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | APP / Beta Amyloid Precursor Antibody (aa44-63) LS-C56816. Recognizes amyloid precursor protein (APP), a 130 kD member of the APP family, expressed in adult brain. It is a cell surface kinesin I membrane receptor which regulates the axonal transport of beta-secretase and presenilin 1. In Alzheimer's disease processing of APP by beta-secretase gives rise to amyloidogenic 42 AA beta amyloid protein that is found in senile plaques and vessels. APP binds components of the extracellular matrix such as heparin and collagen I and IV, regulating neurite growth and is also involved in neuronal adhesion, cell mobility and axonogenesis. Through it's binding to APBB1/Tip60, APP plays a role in the regulation of transcription. APP also inhibits Notch signaling through it's interaction with Numb. |
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| Immunogen | Synthetic peptide corresponding to the amino acid sequence 44-63 of human amyloid precursor protein. |
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| Other Names | APP, ABPP, A4, ABETA, AD1, Alzheimer disease, Amyloid beta, Beta-amyloid peptide, APPI, Beta amyloid, CVAP, AAA, PN2, PreA4, Amyloid beta A4 protein, Peptidase nexin-II, CTFgamma, PN-II, Protease nexin-II |
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| Gene, Accession # | APP, Gene ID: 351 |
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| Catalog # | LS-C56816 |
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| Order / More Info | APP / Beta Amyloid Precursor, aa44-63 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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