| 产品详情 |
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| Antigenic Specificity | C5a Receptor (C5AR) |
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| Clone | S5-1 was raised against a synthetic peptide comprising the N-terminal domain of the C5aR (Met1-Asn31)-The antibody has been shown to inhibit the binding of C5a to its receptor-Aliases Complement component 5a receptor 1-CD88-C5aR-C5a anaphylatoxin receptor |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | unconjugated |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The monoclonal antibody S5/1 recognizes the human receptor for C5a (CD88). The C5a receptor is a seven transmembrane GTP-binding-protein-coupled receptor of 45kDa which binds with high affinity to human anaphylatoxin C5a. Upon C5a binding G-protein-dependent cellular responses are initiated 2+ such as increased intracellular Ca , granule fusion with the cell membrane, enzyme release and oxidative burst suggesting that C5aR is an important mediator of inflammation. The C5a receptor is expressed on a broad range of cell types, including neutrophils, monocytes/macrophages, dendritic cells, astrocytes and microglia. Interestingly, C5a receptor signalling has been associated with several inflammatory diseases including rheumatoid arthritis. |
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| Immunogen | n/a |
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| Other Names | n/a |
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| Gene, Accession # | n/a |
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| Catalog # | ABIN2191970 |
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| Price | |
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| Order / More Info | C5a Receptor (C5AR) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 8376805, 7835913, 9049041, 10447728, 19789912 |
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