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| Antigenic Specificity | Protein Arginine Methyltransferase 6 (PRMT6) (aa 324-374) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | rhesus monkey, human, rat |
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| Isotype | n/a |
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| Format | serum |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). It thereby acts as a transcription corepressor of various genes such as HOXA2. Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to stimulate the polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC). SUBCELLULAR LOCATION: Nucleus Tissue specificity: Highly expressed in kidney and testis.Synonyms: Chromobox protein homolog 7 |
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| Immunogen | A synthetic peptide from aa region 324-374 of Rhesus macaque PRMT6 conjugated to an immunogenic carrier protein was used as the antigen. |
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| Other Names | CG9927|DART6|Dmel\\CG9927|PRMT6|HRMT1L6|ARABIDOPSIS THALIANA PROTEIN ARGININE METHYLTRANSFERASE 6|ATPRMT6|protein arginine methyltransferase 6|DKFZp459B1431|Hrmt1l6|hrmt1l6|hrmt6|im:6908706|AW124876|BB233495 |
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| Gene, Accession # | Gene ID: 694284,55170,295384 |
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| Catalog # | ABIN1841843 |
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| Price | |
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| Order / More Info | Protein Arginine Methyltransferase 6 (PRMT6) (aa 324-374) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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