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| Product Name | HMG-CoA Reductase Activity/Inhibitor Screening Kit (Color) |
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| Description | HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) (EC 1.1.1.34) is the rate-controlling enzyme of the mevalonate pathway, the metabolic pathway that produces cholesterol from acetyl-CoA. In an NADPH-dependent reaction, HMG-CoA reductase reduces HMG-CoA to generate mevalonate and CoA. The enzyme is target of a group of cholesterol-lowering drugs known as statins. Inhibition of HMG-CoA reductase induces expression of LDL receptors in the liver, which lowers plasma concentration of cholesterol. The HMG-CoA Reductase Activity Assay Kit measures utilization of NADPH, which can be measured by the decrease of absorbance (OD 340 nm). The kit is suitable for measuring activity of purified enzyme and screening inhibitors/activators of HMG-CoA reductase. The limit of detection is below 0.05 mU. Sample types: partially purified recombinant enzyme |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | Measurement of HMG-CoA reductase activityScreening/studying/characterizing HMG-CoA reductase inhibitors/activators |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-K597 |
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| Order / More Info | HMG-CoA Reductase Activity/Inhibitor Screening Kit (Color) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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