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| Product Name | HMG-CoA Reductase, Control Peptide, Human (3-hydroxy-3-methylglutaryl-coenzyme A reductase) |
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| Description | Purity > 90% by HPLC. Synthetic (linear) peptide (AcCKDNPGENARQLAR- NH2) corresponding to aa827-840 of human HMG-CoA Reductase with an N-terminal cysteine added for conjugation. The peptide has the amino terminus blocked with an acetyl group and the carboxyl terminus blocked with an amide group. The HMG-CoA reductase pathway, also known as MVA pathway or mevalonate-dependent (MAD) route, is an important cellular metabolic pathway present in virtually all organisms. It forms hydrophobic molecules for tasks as diverse as cell membrane maintenance, hormones, protein anchoring and N-glycosylation. Regulation and feedback: Several key enzymes can be activated through DNA transcriptional regulation on activation of SREBP (Sterol Regulatory Element Binding Protein 1 and 2). This intracellular sensor detects low cholesterol levels and stimulates endogenous production by the HMG-CoA reductase pathway, as well as increasing lipoprotein uptake by up-regulating the LDL receptor. Regulation of this |
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| Size | 1mg |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | AcCKDNPGENARQLAR- NH2 |
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| Gene, Accession, CAS # | Accession: NM_000859 |
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| Catalog # | H6201-10A |
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| Order / More Info | HMG-CoA Reductase, Control Peptide, Human (3-hydroxy-3-methylglutaryl-coenzyme A reductase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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