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| Product Name | sFas Ligand, Recombinant, Human (soluble Fas Ligand (sFasL), TNFSF6, CD95L, Apo I Ligand, APTL) |
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| Description | Purity ≥95% by SDS-PAGE gel and HPLC analyses. Fas Ligand (FasL) is a member of the TNF superfamily that is expressed on the cell surface of activated T cells.Binding of FasL to Fas Receptor triggers apoptosis in Fas-bearing cells.FasL has the ability to kill T cells and activated B cells which leads to down-regulation of the immune response.The mechanism of Fas induced apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms.These active caspases then cleave various cellular substrates leading to the eventual cell death.Both human and murine sFasL are fully active on human and murine cells.Recombinant human soluble Fas Ligand is a 17.9kD protein comprising the TNF homologous region of FasL and contains an 8 residue N-terminal His-Tag. Biological Activity: Determined by it's ability to induce cytotoxicity in Jurkat cells in the absence of any cross-linking. The ED50 for this effect is ~10.0ng/ml, co |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 143500 |
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| Order / More Info | sFas Ligand, Recombinant, Human (soluble Fas Ligand (sFasL), TNFSF6, CD95L, Apo I Ligand, APTL) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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