| 产品详情 |
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| Product Name | coumarin-SAHA |
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| Description | Purity >98%. Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino cap group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. 2 The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively and is quenched by 50% when bound to HDAC8. This probe can be used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes and is well-suited for high-throughput screening. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N1-hydroxy-N8-(4-methyl-2-oxo-2H-chromen-7-yl)-octanediamide, coumarin-Suberoylanilide Hydroxamic Acid |
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| Gene, Accession, CAS # | CAS: 1260635-77-5 |
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| Catalog # | LS-H7242 |
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| Price | |
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| Order / More Info | coumarin-SAHA from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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