| 产品详情 |
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| Product Name | Iso-Olomoucine |
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| Description | Purity >98%. Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression whose function/dysfunction has been implicated in cancer, a subset of human neurodegenerative diseases, and the reward response of addictive drugs via alteration of postsynaptic dopamine receptor signaling. Iso-olomoucine is an inactive stereoisomer of the Cdk5 inhibitor olomoucine. Because iso -olomoucine lacks activity at Cdk5 (IC50 = 1 mM)1, it may have utility as a control compound for determining Cdk5 specificity. In a Cdk5-independent manner, iso -olomoucine has been shown to rapidly inhibit dopamine transporter activity in rat dorsal striatal synaptosomes with a potency similar to that of olomoucine (IC50 ~37 µM). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[[7-methyl-6-[(phenylmethyl)amino]-7H-purin-2-yl]amino]-ethanol |
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| Gene, Accession, CAS # | CAS: 101622-50-8 |
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| Catalog # | LS-H8249 |
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| Order / More Info | Iso-Olomoucine from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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