| 产品详情 |
| Edit |   |
|---|
| Product Name | ICG-001 |
|---|
| Description | Purity >98%. ICG-001 is a small molecule inhibitor of Beta-catenin/cyclic AMP responsive element binding protein binding protein (CBP)-mediated transcription (IC50 = 3 µM). By binding CBP, thus blocking interaction with Beta-catenin, it selectively induces apoptosis in transformed colon cells but not in normal cells and prevents the growth of colon carcinoma cells at 25 µM in vitro . ICG-001 has been used to specifically disrupt the Beta-catenin pathway in studying epithelial-mesenchymal transition during pulmonary fibrosis. Additionally, ICG-001 disruption of Wnt/Beta-catenin signaling has been studied in the context of regulating cancer stem cells. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | (6S,9aS)-hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide |
|---|
| Gene, Accession, CAS # | CAS: 847591-62-2 |
|---|
| Catalog # | LS-H8167 |
|---|
| Price | |
|---|
| Order / More Info | ICG-001 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|