| 产品详情 |
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| Product Name | LYP Inhibitor II, LTV-1 |
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| Description | Purity ~98% (HPLC). A cell-permeable thiobarbituryl-benzoate compound that acts as a highly potent and reversible inhibitor of lymphoid tyrosine phosphatase (LYP) (IC50=508nM) and thereby enhances TCR signaling in intact cells. Exhibits competitive to mixed mode of inhibition (Ki=384nM). Also shown to inhibit the mutant, disease associated LYP-Trp620 activity. Binds to the phosphate-binding loop and mimicks the phosphotyrosine moiety of substrates. Displays acceptable selectivity over a wide range of protein phosphatases (TCPTP, PTP1B, PEP (mouse LYP), SHP1, CD45 and PTP-PEST: IC50=1.52, 1.59, 7.56, 23.2, 30.1, and 100uM, respectively). Does not exhibit any toxicity at pharmacological doses when tested in primary human cell lines. Formula: C26H20N2O5S Molecular Weight: 472.5 Solubility: DMSO (50mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | LYP Inhibitor II, LTV-1 (Lymphoid Tyrosine Phosphatase Inhibitor II, LTV-1, (E)-3-((4-((4,6-Dioxo-2-thioxo-1-o-tolyltetrahydropyrimidin-5(6H)-ylidene)methyl)phenoxy)methyl)benzoic Acid) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217529 |
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| Order / More Info | LYP Inhibitor II, LTV-1 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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