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| Product Name | Delta4-Dafachronic Acid |
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| Description | Purity >95%. During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans . DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. Delta4 -Dafachronic acid is a racemic version of a sterol-derived hormone that acts as a ligand of DAF-12. Delta4 -Dafachronic acid binds to and transactivates DAF-12, rescuing hormone deficiency in transgenic dauer larvae and promoting reproductive maturation into adults. The (25S) diastereomer of Delta4 -dafachronic acid is significantly more potent than its (25R) counterpart (EC50 s = 23 and 66 nM, respectively). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-oxo-cholest-4-en-26-oic acid, 3-keto-4-Cholestenoic Acid |
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| Gene, Accession, CAS # | CAS: 23017-97-2 |
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| Catalog # | LS-H10637 |
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| Price | |
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| Order / More Info | Delta4-Dafachronic Acid from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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