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| Product Name | UBE3A, Recombinant, Human, 6-His tag, |
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| Description | Purity ~95% (SDS-PAGE). E6AP (E6-Associated Protein) is a HECT domain ubiquitin E3 ligase that ubiquitinates and mediates the proteasomal destruction of substrate proteins. HECT domain ligases use an active site cysteine to accept charged ubiquitin from ubiquitin-E2 thioester complexes for subsequent transfer to substrate proteins; in this way HECT class ligases are distinct from most RING class ligases in that the latter facilitate transfer of ubiquitin from charged E2's directly to substrate proteins without an E3-ubiquitin thioester intermediate. The viral HPV-E6 protein (present in cells infected with human papillomavirus) forms a complex with E6AP to generate a ligase activity that polyubiquitinates the tumor suppressors p53 and p73 and targets them to the 26S proteasome for degradation. This protein contains a C-terminal 6-His tag. Source: Recombinant protein corresponding to human His6-E6AP/UBE3A, CF. Molecular Weight: ~102kD |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | UBE3A, Recombinant, Human, 6-His tag, (ANCR, E6AP, EPVE6AP, HPVE6A, Human Papillomavirus E6-associated Protein, E6-associated Protein) |
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| Gene, Accession, CAS # | SwissProt: Q05086 |
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| Catalog # | 145855 |
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| Order / More Info | UBE3A, Recombinant, Human, 6-His tag, from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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