| 产品详情 |
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| Antigenic Specificity | Human ANGPT4 |
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| Clone | 267321 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA(Cap) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Mouse Anti-Human ANGPT4 monoclonal antibody for ELISA(Cap). Human Angiopoietin-4 (Ang-4) , alternatively named Ang-3 , is a secreted glycoprotein belonging to the angiopoietin family. It has the characteristic structural motifs of angiopoietins including the coiled-coiled domain near the amino-terminus and a fibrinogen-like domain at the C-terminus. Human Ang-4 cDNA encodes a 503 amino acid (aa) precursor protein with a 23 aa signal peptide. It shares 45%, 47% and 54% aa sequence identity with human Ang-1, human Ang-2 and mouse Ang-3, respectively. Although the sequence homology is much higher between the human and mouse counterparts for Ang-1 and Ang-2 , mouse Ang-3 is believed to be an ortholog of human Ang-4 based on chromosomal localization studies. Human Ang-4 is highly expressed in lung and in cultured human umbilical vein endothelial cells (HUVECs). In contrast, mouse Ang-3 is expressed multiple mouse tissues. Human Ang-4 is an agonist that can bind and activate Tie-2, a receptor tyrosine kinase with immunoglobulin and epidermal growth factor homology domains expressed primarily on endothelial cells and early hematopoietic cells. Mouse Ang-3 has been reported to be a Tie-2 antagonist. It is likely that mouse Ang-3, like Ang-2, may exert agonist or antagonist activities depending on the cell context. |
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| Immunogen | Recombinant Protein |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 51378, UniProt: Q9Y264 |
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| Catalog # | CABT-L159 |
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| Order / More Info | Human ANGPT4 Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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