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| Product Name | Retinoblastoma, Recombinant Fusion Protein, aa701-928, Negative and Positive Control (Rb) |
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| Description | The retinoblastoma tumor suppressor protein Rb regulates cell proliferation by controlling progression through the restriction point within the G1-phase of the cell cycle (1). Rb has three functionally distinct binding domains and interacts with critical regulatory proteins including the E2F family of transcription factors, c-Abl tyrosine kinase and proteins with a conserved LXCXE motif (2-4). Cell cycle-dependent phosphorylation by cdk's inhibits Rb target binding, thus allowing cell cycle progression (5). Rb inactivation and subsequent cell cycle progression likely requires first phosphorylation by cyclin D-cdk4/6 followed by cyclin E-cdk2 phosphorylation (6). Specificity of different cdk/cyclin complexes has been observed in vitro (6-8) and cyclin D1 is required for Ser780 phosphorylation in vivo (9). R1665A Rb-C Fusion Protein Non-Phosphorylated 1x100ul Rb-C is expressed as a recombinant fusion protein of Rb residues 701-928 and maltose binding protein, serves as a negative control |
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| Size | 1 kit |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 5925, SwissProt: P06400 |
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| Catalog # | R1665 |
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| Order / More Info | Retinoblastoma, Recombinant Fusion Protein, aa701-928, Negative and Positive Control (Rb) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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