| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | Equine IL4 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Goat |
|---|
| Reactive Species | equine |
|---|
| Isotype | n/a |
|---|
| Format | biotin conjugate |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | ELISA(Det), WB |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Goat Anti-Equine IL4 polyclonal antibody for ELISA(Det), WB. Interleukin-4 (IL-4), also known as B cell-stimulatory factor-1, is a monomeric, approximately 13-18 kDa Th2 cytokine that shows pleiotropic effects during immune responses. It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four alpha-helix structure. Equine IL-4 is synthesized with a 24 amino acid (aa) signal sequence. Mature equine IL-4 shares 53-60% aa sequence identity with bovine, goat, human, ovine, and porcine IL-4 and 38-40% aa sequence identity with mouse and rat IL-4. IL-4 exerts its effects through two receptor complexes. The type I receptor, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R alpha and the common gamma chain (a shared subunit of the receptors for IL-2,-7,-9,-15, and-21). The type II receptor on non-hematopoietic cells consists of IL-4 R alpha and IL-13 R alpha 1. The type II receptor also transduces IL-13 mediated signals. IL-4 is primarily expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgE in B cells, acquisition of the Th2 phenotype by naive CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL-4 plays a dominant role in the development of allergic inflammation and asthma. |
|---|
| Immunogen | Recombinant Protein |
|---|
| Other Names | n/a |
|---|
| Gene, Accession # | UniProt: A7LBR9 |
|---|
| Catalog # | CABT-L144 |
|---|
| Price | |
|---|
| Order / More Info | Equine IL4 Antibody from CREATIVE DIAGNOSTICS |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|