| 产品详情 |
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| Antigenic Specificity | Human Bim (phospho Ser69) |
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| Clone | L.835.5 |
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| Host Species | Rabbit |
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| Reactive Species | dog, human, mouse, nonhuman primate, rat |
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| Isotype | IgG |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | IP, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit Anti-Human Bim (phospho Ser69) monoclonal antibody for IP, WB. The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. |
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| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer69 of human Bim protein |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 10018, UniProt: O43521 |
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| Catalog # | CABT-L1209 |
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| Price | |
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| Order / More Info | Human Bim (phospho Ser69) Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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