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| Product Name | PICK1 PDZ Domain Inhibitor, FSC231 ((E)-Ethyl-2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate) |
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| Description | Purity ~95% (HPLC). A cell-permeable acryloylcarbamate compound that selectively targets the PDZ (PSD-95/Discs-large/ZO-1 homology) domain of PICK1 (protein interacting with C kinase 1), but not those of PSD-95 (postsynaptic density protein 95) and GRIP1 (glutamate receptor interacting protein 1), effectively competing against dopamine transporter/DAT (Ki ~10uM), GluR2 (Ki ~10uM), and mRluR7a, c-terminus binding to PICK1 PDZ. Shown to accelerate internalized GluR2 surface recycling and suppress both long-term depression and potentiation in rat and murine hippocampal neurons. Formula: C13H10Cl2N2O3 Molecular Weight: 313.1 Solubility: DMSO (100mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217658 |
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| Order / More Info | PICK1 PDZ Domain Inhibitor, FSC231 ((E)-Ethyl-2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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