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| Product Name | PICK1, Recombinant, Human, aa1-200, GST-Tag (PRKCA-binding Protein) |
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| Description | Purity ~90% (SDS-PAGE). Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. Source: Recombinant prot |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Protein interacting with C kinase 1, Protein kinase C-alpha-binding protein |
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| Gene, Accession, CAS # | SwissProt: Q9NRD5 |
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| Catalog # | 374706 |
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| Order / More Info | PICK1, Recombinant, Human, aa1-200, GST-Tag (PRKCA-binding Protein) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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