| 产品详情 |
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| Product Name | Dihydroorotate Dehydrogenase Inhibitor, Brequinar |
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| Description | Purity ~98% (HPLC). A quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100uM). Primary Target: DHODH Primary Target IC50: 12nM Solubility: DMSO |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Dihydroorotate Dehydrogenase Inhibitor, Brequinar (6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic Acid Sodium Salt, NSC 368390, DuP 785) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217314 |
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| Order / More Info | Dihydroorotate Dehydrogenase Inhibitor, Brequinar from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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