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| Product Name | Ezrin Inhibitor, NSC668394 (7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione) |
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| Description | Purity ~95% (HPLC). A cell-permeable, quinoline that binds directly to ezrin (=12.6uM) in a reversible manner, and inhibits PKCι-mediated ezrin phosphorylation at Thr567 (IC50=8.1uM) and ezrin-actin binding, in vitro. It also inhibits murine osteosarcoma K7M2 cell invasion in a monolayer of HUVEC cells, dose-dependently, from 1 to 10uM. At 10uM, it causes a unique developmental defect in zebrafish, characterized by reduced motility of eye progenitor cells. Furthermore, this small molecule prevents metastatic growth in an ex vivo mouse lung organ culture assay at 10uM and attenuates ezrin-dependent OS metastatic growth in mouse lung model in vitro at 2.26mg/kg/day. Formula: C17H12Br2N2O3 Molecular Weight: 449.9 Solubility: DMSO (50mg/ml, clear, red-orange solution) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217351 |
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| Order / More Info | Ezrin Inhibitor, NSC668394 (7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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