| 产品详情 |
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| Antigenic Specificity | BUB3 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b,k |
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| Format | purified |
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| Size | 100ul, 50ul |
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| Concentration | n/a |
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| Applications | ELISA, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BUB3 (budding uninhibited by benzimidazoles 3 homolog) is a conserved component of the mitotic spindle assembly complex (MCC). It contains five WD repeat domains and forms cell cycle constitutive complexes with BUB1 and BUBR1. BUB3 is essential for the kinetochore localization of BUB1 and BUBR1. As a component of the MCC, BUB3 is involved in the essential spindle checkpoint pathway that operates during early embryogenesis. The spindle checkpoint pathway functions to postpone the initiation of anaphase until chromosomes are properly attached to the spindle. This acts to ensure accurate chromosome segregation. In addition, BUB3 plays a role in regulating the establishment of correct kinetochore-microtubule attachments. |
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| Immunogen | Recombinant human BUB3 (1-328aa) purified from E. coli |
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| Other Names | Mitotic checkpoint protein BuB3, BuB3L, hBuB3 |
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| Gene, Accession # | NP 004716 |
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| Catalog # | ATGA0319 |
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| Price | |
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| Order / More Info | BUB3 Antibody from ATGen |
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| Product Specific References | n/a |
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