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| Product Name | DNMT3A, Recombinant, Human, aa680-902, His-Tag (DNA (Cytosine-5)-Methyltransferase 3A) |
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| Description | Purity ~90% (SDS-PAGE). Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. Source: Recombinant protein corresponding to aa680-902 from human DNMT3A, fused to His-Tag at N-terminal expressed in E. coli. Molecular Weight: ~29.9kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA |
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| Gene, Accession, CAS # | SwissProt: Q9Y6K1 |
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| Catalog # | 373085 |
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| Order / More Info | DNMT3A, Recombinant, Human, aa680-902, His-Tag (DNA (Cytosine-5)-Methyltransferase 3A) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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