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| Product Name | Protein C Inhibitor-Activated Protein C Complex (PCI-APC Compex), BioAssay™ ELISA Kit (Antibodies only) |
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| Description | Activation of coagulation leads to the generation of thrombin which, in the presence of thrombomodulin, will activate Protein C to the enzyme activated Protein C (APC). Unless regulated, APC will exert its anticoagulant function through proteolytic inactivation of factor Va and factor VIIIa. In blood, the activity of APC is regulated in part through interaction with protease inhibitors to form inactive enzyme- inhibitor complexes. Based on physiological concentrations and the kinetics of inhibition, the primary inhibitor of APC in blood is Protein C Inhibitor (PCI, also known as plasminogen activator inhibitor-3), followed by alpha-1 antitrypsin (alpha-1AT, also known as alpha-1proteinase inhibitor) and alpha-2 macroglobulin. The APC-PCI complex (APC-PCI) results when APC cleaves a scissile bond near the C-terminus of PCI, forming a covalent 1:1 acyl- enzyme intermediate with PCI with an apparent mass of 110 kD. Calcium is not required for this interaction, but the rate of APC inhibiti |
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| Size | 1 kit |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P9102-37 |
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| Order / More Info | Protein C Inhibitor-Activated Protein C Complex (PCI-APC Compex), BioAssay™ ELISA Kit (Antibodies only) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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