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| Product Name | CHIP, 1-303aa, Human, E Coli |
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| Description | MW: 34.8 kDa (303 aa), confirmed by MALDI-TOF. Purity >90% by SDS-PAGE. CHIP, also known as STuB1, is a cytoplasmic protein whose amino acid sequence is highly conserved across species. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, whereas its u-box domain contains its E3 ubiquitin ligase activity. Its interaction with these molecular chaperones results in client substrate ubiquitylation and degradation by the proteasome. Thus, CHIP acts to tilt the f |
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| Size | 0.1 mg, 0.5 mg |
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| Concentration | 1 mg/ml (determined by Bradford assay) |
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| Applications | SDS-PAGE |
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| Other Names | [Carboxy terminus of HSP70 interacting protein; STuB1; HSPABP2; NY-CO-7; SDCCAG7; uBOX1; Carboxy terminus of HSP70 interacting protein Antigen NY CO 7; CLL associated antigen KW 8; Carboxy terminus of Hsp70p interacting protein; CHIP; E3 ubiquitin protein ligase CHIP; STuB 1; uBOX 1; Heat shock protein A binding protein 2 (c terminal); NY CO 7; Serologically defined colon cancer antigen 7; STIP1 homology and u Box containing protein 1.] |
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| Gene, Accession, CAS # | CHIP, Gene ID: 10273, Accession: NP_005852 |
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| Catalog # | MBS203190 |
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| Order / More Info | CHIP, 1-303aa, Human, E Coli from MYBIOSOURCE INC. |
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| Product Specific References | Kajiro M., et al. (2009) Nat Cell Biol. 11 (3):312-9.; Ko HS., et al. (2009) Proc Natl Acad Sci. 106 (8):2897-902.; |
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