| 产品详情 |
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| Product Name | Beclin-1 Activator II, Retro-inverso TAT-Beclin-1 |
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| Description | Purity ~95% (HPLC). A cell-permeable, all-D-amino acid autophagy-inducing peptide based on the retro-inverso sequence of Tat-Beclin1 that is expected to be more resistant to proteolytic degradation than Tat-Beclin1 and is shown to be more potent than Tat-Beclin1 in inducing autophagy in muscle, heart, and pancreas tissues in 6-wk-old GFP-LC3 transgenic mice (20mg/kg i.p.) in vivo. Only the retro-inverso peptide, but not Tat-Beclin1, is effective in reducing autophagy substrate p26 level in the brain tissue of 5-d-old neontal GFP-LC3 mice (20mg/kg i.p.). The retro-inverso peptide treatment is also reported to greatly reduce brain viral titre in neonatal mice subjected to West Nile Virus infection. Sequence: (D)-H-arg-arg-arg-gln-arg-arg-lys-lys-arg-Gly-tyr~Gly-Gly~thr-Gly-phe-glu-Gly-asp-his-trp-ile-glu-phe-thr-ala-asn-phe-val-asn-thr-OH Solubility: DMSO or H2O Primary Target: GAPR-1/GLIP |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Beclin-1 Activator II, Retro-inverso TAT-Beclin-1 ((D)-H2N-RRRQRRKKRGY-GG-TGFEGDHWIEFTANFVNT-CO2H, Atg6 Activator II, Beclin-1-GAPR-1 Interaction Blocker II, Vps30 Activator II) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217214 |
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| Order / More Info | Beclin-1 Activator II, Retro-inverso TAT-Beclin-1 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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