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| Product Name | BUB1B, Recombinant, Human, GST-tag |
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| Description | Purified (~70-90%). BUB1B or budding uninhibited by benzimidazoles 1 homolog beta is involved in spindle checkpoint function and has been localized to the kinetochore. BUB1B plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. BUB1B links the regulation of chromosome-spindle attachment to mitotic checkpoint signaling. BUB1B expression during the spindle checkpoint is dependent on residual BUB1B expression and impaired spindle checkpoint function has been found in many forms of cancer. BUB1B is essential for early embryonic development and normal hematopoiesis. Source: Recombinant protein corresponding to human BUB1B, fused to GST-Tag at N-terminal, expressed in Insect cells. Molecular Weight: ~73kD Specific Activity: 1.5nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | BUB1B, Recombinant, Human, GST-Tag (Budding Uninhibited by Benzimidazoles 1 Homolog beta, SSK1, BUBR1, Bub1A, MAD3L, hBUBR1, BUB1beta) |
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| Gene, Accession, CAS # | Accession: NM_001211 |
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| Catalog # | 499831 |
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| Order / More Info | BUB1B, Recombinant, Human, GST-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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