| 产品详情 |
| Edit |   |
|---|
| Product Name | Cerebellin, Recombinant, Human, HA-tag |
|---|
| Description | Purity ~95% (SDS-PAGE). CBLN1 is a 35kD secreted glycoprotein in the Cerebellin family of TNF superfamily molecules. Cerebellins contain an N-terminal collagenous domain and a C-terminal TNF/C1q-like domain. Mature human Cerebellin-1 shares 100% aa sequence identity with mouse and rat Cerebellin-1. It is expressed in the cerebellum, the parafascicular nucleus of the thalamus, and in the adrenal cortex and pancreatic islets. Cerebellin-1 forms noncovalent homotrimers that are disulfide-linked into hexamers. It can also form hetero-oligomers with Cerebellins-2, -3, and -4 and is required for the secretion of Cerebellin-3. Cerebellin-1 is subject to proteolysis which can liberate 15-mer or 16-mer bioactive peptides from the C1q domain or remove the regions necessaryfor trimer or hexamer formation. Formation of the hexamer is required for Cerebellin-1's ability to bind to synaptic structures. It binds to postsynaptic densities through direct interactions with the glutamate receptor subunit |
|---|
| Size | 25ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Cerebellin, Recombinant, Human, HA-tag (YPYDVPDYA tag, Cerebellin 1, Cerebellin-1, CBLN1, Precerebellin) |
|---|
| Gene, Accession, CAS # | SwissProt: P23435 |
|---|
| Catalog # | C2790-48C |
|---|
| Price | |
|---|
| Order / More Info | Cerebellin, Recombinant, Human, HA-tag from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|