| 产品详情 |
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| Product Name | SB-207266 |
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| Description | Purity >95%. The indole derivative SB-207266 is a selective and potent antagonist of the serotonin (5-HT) receptor 5-HT4 with a pA2 value of 10.6 ± 0.1. In COS7 cells, 100 nM SB-207266 inhibited 5-HT4 responses to 5-HT and reduced basal agonist-independent cAMP production. In several animal models, low concentrations of SB-207266 blocked exogenous 5-HT-mediated sensitization of intestinal peristalsis. In a dog model, SB-207266 (0.1-100 pg/kg) dose-dependently reduced responses to 5-HT, with an ID50 value of 1.3 pg/kg. SB-206226 (0.5 mg/kg/24 h) improved cardiac function in a rat model of congestive heart failure. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[(1-butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide, Piboserod |
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| Gene, Accession, CAS # | CAS: 152811-62-6 |
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| Catalog # | LS-H9839 |
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| Order / More Info | SB-207266 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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