| 产品详情 |
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| Product Name | SB-366791 |
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| Description | Purity >98%. The transient receptor potential vanilloid type 1 (TRPV1) receptor is a nonselective cation channel gated by noxious heat, protons, and capsaicin. TRPV1 is present in primary sensory neurons and in both central and peripheral sensory nerve terminals and plays a role in thermal and mechanical hyperalgesia. SB-366791 is a selective TRPV1 antagonist that is widely used in pain research. In cultured trigeminal ganglion neurons, SB-366791 inhibits capsaicin-evoked Ca2+ influx with an IC50 value of 0.7 µM. A 1 nmol injection of SB-366791 in mouse paw reduces capsaicin-induced nociceptive responses in a model of pain. Intrathecal pretreatment of 10 µl SB-366791 in rats suppresses tolerance to the analgesic effects of chronic morphine administration. Co-administration of morphine and SB-366791 at 0.1 mg/kg has potent analgesic effects in a mouse model of bone cancer pain. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide |
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| Gene, Accession, CAS # | CAS: 472981-92-3 |
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| Catalog # | LS-H9847 |
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| Order / More Info | SB-366791 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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