| 产品详情 |
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| Product Name | SB-525334 |
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| Description | Purity >98%. SB-525334 is a potent inhibitor of the TGF-Beta receptor 1 (TGF-Beta R1, ALK5) kinase (IC50 = 14.36 nM). It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6. SB-525334 blocks TGF-Beta1-induced phosphorylation and nuclear translocation of SMAD2/3 as well as TGF-Beta1-directed gene expression. It is effective in vivo, preventing puromycin aminonucleoside-induced renal fibrosis and bleomycin-induced pulmonary fibrosis. SB-525334 also modulates carcinogenesis and suppresses the development of pulmonary arterial hypertension in animals. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-[2-(1,1-dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]-quinoxaline, TGF-Beta RI Kinase Inhibitor VIII |
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| Gene, Accession, CAS # | CAS: 356559-20-1 |
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| Catalog # | LS-H9853 |
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| Order / More Info | SB-525334 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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