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| Product Name | D-Amino Acid Oxidase Inhibitor III, AS057278 |
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| Description | Purity ~99% (HPLC). A cell-permeable pyrazolocarboxylic acid that acts as a selective D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) inhibitor (IC50 = 910nM against human DAO; [D-ser] = 10mM) and effectively protects DAO overexpressing cultures from oxidative stress-induced cell death upon D-Ser (50mM) exposure (ED50 ≤3.95uM), while exhibiting little affinity toward nMDAR glycine binding site or inhibitory activity against D-aspartate oxidase (DDO/DSOX). Reported to be orally available and blood-brain barrier-permeant in rats and effectively prevent PCP (phencyclidine) from suppressing PPI (prepulse inhibition) response in mice (single 80mg/kg or 56X 20mg/kg/12h b.i.d. oral dosages) in vivo. Formula: C5H6N2O2 Solubility: DMSO Primary Target: DAAO Primary Target IC50: 910nM Molar Mass: 126.11 |
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| Size | 50mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | D-Amino Acid Oxidase Inhibitor III, AS057278 (5-methyl-1H-pyrazole-3-carboxylic Acid, DAAO Inhibitor III) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217308 |
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| Order / More Info | D-Amino Acid Oxidase Inhibitor III, AS057278 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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