| 产品详情 |
| Edit |   |
|---|
| Product Name | Daminozide |
|---|
| Description | Purity ~98% (NMR). A dimethylamino substituted succinamate that, in addition to its well known use as a plant growth regulator, also acts as an inhibitor against histone lysine demthylases KDM2A, LSD1 (KDM7A; KIAA1718), and PHF8 (IC50 = 1.5, 2.1, and 0.55uM, respectively), but not KDM3A, KDM4E, KDM5C, KDM6B, or three hydroxylases (IC50 >100uM). Substrate-competition and/or active site Iron chelating likely accounts for the inhibitory activity against the FAD-dependent LSD1, while 2-oxoglutarate (2-OG) competition (Ki = 1.97uM) appears as the major mode of action against KDM2A. Formula: C6H12N2O3 Solubility: H2O Molar Mass: 160.2 |
|---|
| Size | 1g |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Daminozide (JHDM Inhibitor VI, N,N-Dimethylamino-succinamic Acid, Succinic Acid-2,2-dimethylhydrazide, 4-(2,2-Dimethylhydrazinyl)-4-oxobutanoic Acid, BHC100 Inhibitor VI, KDM2A Inhibitor, KIAA1718 Inhibitor VI, LSD Inhibitor VI, PHF8 Inhibitor, Histone Lysine Demethylase Inhibitor XII, LSD1 Inhibitor VI) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217311 |
|---|
| Price | |
|---|
| Order / More Info | Daminozide from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|